Clinical Trial

The Role of Serotonin in Compulsive Behavior in Humans: Underlying Brain Mechanisms

Active, Not Recruiting Phase 4
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Summary
The aim of this project is to investigate: * The status of the central serotonin (5-hydroxytryptamine, 5-HT) system in compulsive behaviour and how it is affected by sub-chronic escitalopram administration * The mechanisms underlying how sub-chronic administration of escitalopram affects the central 5-HT system * How changes in cognitive performance, including the balance between habitual and goal-directed mechanisms, are affected in compulsive behaviour by boosting 5-HT function * How functional brain changes in cognitive function measured with magnetic resonance imaging relate to altered 5-HT function following escitalopram administration.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2020-04-03; most recent amendment 2024-12-13.
Status change: Recruiting → Active, Not Recruiting 2024-07-09
Status change: Not Yet Recruiting → Recruiting 2020-08-08
Trial Details
NCT Number NCT04336228
Lead Sponsor Rigshospitalet, Denmark
Collaborators: University of Cambridge, Lundbeck Foundation
Conditions Obsessive-Compulsive Disorder/High Compulsive Individuals, Healthy Individuals
Enrollment 46 participants
Start Date 2020-04-01
Primary Completion 2027-12-31 (estimated)
Study Completion 2027-12-31 (estimated)
Updated on ClinicalTrials.gov 2024-12-18