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The Role of Serotonin in Compulsive Behavior in Humans: Underlying Brain Mechanisms

StatusActive, Not Recruiting
PhasePhase 4
Started
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Record History

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  1. Primary and study completion dates: Aug 1, 2024 to Dec 31, 2027v5
  2. Trial status: Recruiting to Active, Not Recruitingv4 Show 4 more changesShow less
    • Enrollment target: estimated 48 to confirmed 46
    • Primary and study completion dates: Aug 2024 to Aug 1, 2024
    • Eligibility criteria expanded, about 8 words
    • Site details revised
  3. Eligibility criteria expanded, about 34 wordsv3
  4. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Apr 2020 to Apr 1, 2020
    • Site details revised
    v2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The aim of this project is to investigate: * The status of the central serotonin (5-hydroxytryptamine, 5-HT) system in compulsive behaviour and how it is affected by sub-chronic escitalopram administration * The mechanisms underlying how sub-chronic administration of escitalopram affects the central 5-HT system * How changes in cognitive performance, including the balance between habitual and goal-directed mechanisms, are affected in compulsive behaviour by boosting 5-HT function * How functional brain changes in cognitive function measured with magnetic resonance imaging relate to altered 5-HT function following escitalopram administration.
Trial Details
NCT Number NCT04336228
Lead Sponsor Copenhagen University Hospital, Rigshospitalet
Collaborators: University of Cambridge, Lundbeck Foundation
Conditions
(from sponsor)		 Obsessive-Compulsive Disorder/High Compulsive Individuals, Healthy Individuals
Enrollment 46 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov