Clinical Trial

Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis

Recruiting
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Record status
This record was last updated August 7, 2025 (before its estimated December 2025 completion). Its status may not reflect the trial's current state.
Summary
The focus of this proposal is on overweight (25\>BMI\<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some overweight individuals there is a "metabolic program" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2020-03-23; most recent amendment 2025-08-04.
Status change: Not Yet Recruiting → Recruiting 2021-06-16
Trial Details
NCT Number NCT04320264
Lead Sponsor East Carolina University
Collaborators: Duke University, University of Arkansas
Conditions Metabolic Inflexibility
Enrollment 100 participants
Start Date 2020-03-03
Primary Completion 2025-12 (estimated)
Study Completion 2025-12 (estimated)
Updated on ClinicalTrials.gov 2025-08-07