The PRIME-CRC Trial to Promote CRC Screening in Rural Communities

The investigators will expand an existing, patient-centered, health literacy strategy to promote longer-term adherence to colorectal cancer (CRC) screening in resource-limited, rural health clinics via colonoscopy or annual fecal immunochemical test (FIT). In the proposed 2-arm study, both PRIME-CRC and enhanced usual care (control) will incorporate health literacy evidence-based practices for delivering CRC patient information and counseling to aid patient decision making for selecting FIT or colonoscopy, including simplified test instructions. In addition, the PRIME-CRC arm will use a "stepped care" approach for reminding patients on proper CRC screening preparation for scheduled colonoscopy or completion of annual FIT. Patients in the PRIME-CRC arm will receive frequent follow-up contact from their health care provider via audio-recorded, automated call or SMS text, based on patient preference.

NCT Number	NCT04313114
Lead Sponsor	Louisiana State University Health Sciences Center Shreveport Collaborators: National Cancer Institute (NCI), Northwestern University
Conditions	Colorectal Cancer
Enrollment	804 participants
Start Date	2021-09-20
Primary Completion	2025-12-01 (estimated)
Study Completion	2026-05-31 (estimated)
Updated on ClinicalTrials.gov	2025-01-29