Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry

We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the course of this disease and understand its pathophysiology, with a focus on Small Fiber neuropathy. Moreover we will validate the german version of the Malmö POTS Score and establish an easy diagnostic scheme for patients in outpatient care.

NCT Number	NCT04310644
Lead Sponsor	RWTH Aachen University Collaborators: DLR German Aerospace Center
Conditions	Autonomic Neuropathy, Ehlers-Danlos Syndrome Hypermobility Type, Small Fiber Neuropathy, Postural Tachycardia Syndrome
Enrollment	200 participants
Start Date	2019-09-15
Primary Completion	2028-09-15 (estimated)
Study Completion	2029-09-15 (estimated)
Updated on ClinicalTrials.gov	2025-02-04