TRAnexamic Acid for Preventing Blood Loss Following a Cesarean Delivery in Women With Placenta pREVIA

Several randomized, controlled trials, mostly involving women undergoing cesarean delivery, have shown that the prophylactic intravenous administration of 1 g of tranexamic acid after childbirth reduced blood loss. Most were small, single-centre trials with considerable methodologic limitations. It is important to emphasize that none of these RCTs has included women at increased risk of PPH such as placenta previa, a context in which the prevalence of moderate and severe blood loss is significantly higher and where the magnitude of the effect of TXA may highly differ compared to low risk women

NCT Number	NCT04304625
Lead Sponsor	University Hospital, Bordeaux
Conditions	Postpartum Hemorrhage
Enrollment	1,380 participants
Start Date	2020-08-07
Primary Completion	2027-06 (estimated)
Study Completion	2027-09 (estimated)
Updated on ClinicalTrials.gov	2025-02-10