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Maternal Obesity and Offspring Neurodevelopment

Study acronym: Moon
StatusActive, Not Recruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated December 15, 2025 (before its estimated August 30, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. 2 versions Re-verified since Oct 15, 2025, no change to tracked fieldsv8-v9
  2. Enrollment target: 160 to 260 Primary completion date: Apr 30, 2024 to Aug 30, 2026 · Trial status: Recruiting to Active, Not Recruiting · Completion date: Oct 31, 2024 to Oct 31, 2027 · 1 morev7 Show 4 more changesShow less
    • Primary completion date: Apr 30, 2024 to Aug 30, 2026
    • Trial status: Recruiting to Active, Not Recruiting
    • Completion date: Oct 31, 2024 to Oct 31, 2027
    • Site details revised
  3. 3 versions Re-verified since May 20, 2021, no change to tracked fieldsv4-v6
  4. Primary completion date: Apr 2024 to Apr 30, 2024 Completion date: Oct 2024 to Oct 31, 2024v3 Show 1 more changeShow less
    • Completion date: Oct 2024 to Oct 31, 2024
  5. Re-verified, no change to tracked fieldsv2
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Our goals are to characterize the effects of maternal obesity during pregnancy on infant brain development, reveal the neurodevelopmental consequences, and identify possible mechanisms causing these effects. Our overall hypothesis is that maternal obesity during pregnancy exposes the fetus to an inflammatory environment that affects infant brain structural and functional development and consequently neurodevelopmental outcomes. To test this hypothesis, the investigators will recruit normal-weight and obese pregnant women, examine inflammatory markers associated with obese pregnancy, and correlate them with offspring's brain development evaluated using quantitative MRI methods and outcomes evaluated using neurodevelopmental tests.
Trial Details
NCT Number NCT04274140
Lead Sponsor Arkansas Children's Hospital Research Institute
Conditions Healthy
Enrollment 260 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov