Clinical Trial

Deciphering AMD by Deep Phenotyping and Machine Learning- Prospective Study - PINNACLE

Study acronym: PINNACLE

Active, Not Recruiting

Record status

This record was last updated November 12, 2024 (before its estimated June 2025 completion). Its status may not reflect the trial's current state.

Summary

We will conduct a prospective non-interventional study including 400 early AMD patients (=600 untreated early AMD eyes, including both unilateral (AREDS IV) and bilateral (≥AREDS II)) over a minimum of 1 year to specifically investigate the morphological sequence of events preceding the conversion towards late AMD. All patients will be followed by Optical Coherence Tomography (OCT) imaging every 4 months to detect the earliest focal sites of disease progression. As soon as focal areas of change are observed by the Vienna Reading Center (VRC), a targeted follow-up schedule will be triggered to investigate the events at that area of change in a targeted manner.

Protocol Amendment History 5 amendments

This ClinicalTrials.gov record has been amended 5 times since 2020-02-11; most recent amendment 2024-11-07.

Status change: Recruiting → Active, Not Recruiting 2023-02-22

Trial Details

NCT Number	NCT04269304
Lead Sponsor	University of Southampton Collaborators: Imperial College London, University of Basel, Medical University of Vienna, University of Michigan, King's College London, University College, London
Conditions	Age-related Macular Degeneration
Enrollment	429 participants
Start Date	2019-10-28
Primary Completion	2025-06 (estimated)
Study Completion	2025-06 (estimated)
Updated on ClinicalTrials.gov	2024-11-12