Clinical Trial

Randomised Clinical Trial in Treatment Modalities for Cutaneous Leishmaniasis Caused by Leishmania Tropica, in Pakistan

Completed Phase 3
View on ClinicalTrials.gov →
Summary
A four (4) -arm randomised control clinical trial to evaluate miltefosine, thermotherapy and the combination miltefosine-thermotherapy are effective, safe and tolerable alternative treatment options to treat cutaneous leishmaniasis caused by L. tropica, in Pakistan compared to the standard of care.
Protocol Amendment History 4 changes
critical Trial completed 2026-07-31
notable Enrollment reduced: 832 -> 645 participants 2026-07-31
notable Primary completion pushed: 2025-12-31 -> 2026-06-19 2026-07-31
minor Completion pushed: 2026-01-31 -> 2026-06-19 2026-07-31
Trial Details
NCT Number NCT04268524
Lead Sponsor Medecins Sans Frontieres, Netherlands
Conditions Old World Cutaneous Leishmaniasis
Enrollment 645 participants
Start Date 2022-10-07
Primary Completion 2026-06-19 (estimated)
Study Completion 2026-06-19 (estimated)
Updated on ClinicalTrials.gov 2026-07-30