The INVADE Study: INnominate Vein Approach for Central Catheterization in Difficult to cannulatE Patients

Most recent guidelines suggest central venous access must be performed with real-time ultrasound guidance, and the most recommended site for cannulation is internal jugular vein (IJV); however, it is recognized that evidence for other sites is, at present, limited. Besides, guidelines does not account for patients with small vein cross-sectional area and/or respirophasic collapse, which can make the procedure more difficult or even impossible. The investigators aim to compare three different insertion sites for central venous access, with real-time ultrasound guidance

NCT Number	NCT04265703
Lead Sponsor	Hospital Civil de Guadalajara Collaborators: Instituto Jalisciense de Cancerologia
Conditions	Critical Illness
Enrollment	315 participants
Start Date	2024-02-27
Primary Completion	2027-02-28 (estimated)
Study Completion	2027-02-28 (estimated)
Updated on ClinicalTrials.gov	2026-03-12