Clinical Trial

Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery

Study acronym: PENGUIN
Recruiting Phase 3
View on ClinicalTrials.gov →
Record status
This record was last updated February 19, 2025 (before its estimated October 31, 2025 completion). Its status may not reflect the trial's current state.
Summary
PENGUIN is a pragmatic multi-center trial investigating the effects of pre-operative mouthwash and perioperative oxygen on the incidences of pneumonia and surgical site infection (SSI) following major abdominal surgery. Patients will be recruited from low and middle income countries and randomly assigned to a trial treatment arms: a) pre-operative chlorhexidine mouthwash and 80-100% FiO2; b) no pre-operative mouthwash and 80-100% fraction of inspired oxygen (FiO2); c) pre-operative chlorhexidine mouthwash and 21- 30% FiO2; or d) no pre-operative mouthwash and 21-30% FiO2.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2020-02-04; most recent amendment 2025-02-18.
Status change: Not Yet Recruiting → Recruiting 2020-11-23
Trial Details
NCT Number NCT04256798
Lead Sponsor University of Birmingham
Conditions Infection, Pneumonia, Surgical Site Infection, Wound Infection, Surgical Wound Infection, Postoperative Complications, Anesthesia, Communicable Disease +4 more
Enrollment 12,942 participants
Start Date 2020-11-13
Primary Completion 2025-10-31 (estimated)
Study Completion 2026-06-01 (estimated)
Updated on ClinicalTrials.gov 2025-02-19