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Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery

Study acronym: PENGUIN
StatusRecruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated February 19, 2025 (before its estimated October 31, 2025 completion). Its status may not reflect the trial's current state.

Record History

  1. Primary completion date: Oct 31, 2023 to Oct 31, 2025
    • Study sites: 1 to 37
    • Study completion date: Jun 1, 2024 to Jun 1, 2026
    v3
  2. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Apr 1, 2020 to Nov 13, 2020
    • Study sites: 0 to 1
    v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
PENGUIN is a pragmatic multi-center trial investigating the effects of pre-operative mouthwash and perioperative oxygen on the incidences of pneumonia and surgical site infection (SSI) following major abdominal surgery. Patients will be recruited from low and middle income countries and randomly assigned to a trial treatment arms: a) pre-operative chlorhexidine mouthwash and 80-100% FiO2; b) no pre-operative mouthwash and 80-100% fraction of inspired oxygen (FiO2); c) pre-operative chlorhexidine mouthwash and 21- 30% FiO2; or d) no pre-operative mouthwash and 21-30% FiO2.
Trial Details
NCT Number NCT04256798
Lead Sponsor University of Birmingham
Conditions
(from sponsor)		 Infection, Pneumonia, Surgical Site Infection, Wound Infection, Surgical Wound Infection, Postoperative Complications, Anesthesia, Communicable Disease +4 more
Related terms Communicable Diseases, Infections, Pathologic Processes, Pneumonia, Postoperative Complications, Surgical Wound Infection, Wound Infection
Enrollment 12,942 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov