Clinical Trial

Impact of Estradiol on Endothelial Function in Peri-Menopausal Women

Active, Not Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
The purpose of this study is to identify the impact of estradiol (E2) on the mechanisms that regulate vascular endothelial function in peri-menopausal (PERI) women. This study is the first step in understanding factors contributing to endothelial dysfunction in women with advancing reproductive age and in response to E2 administration.
Protocol Amendment History 2 changes
notable Primary completion pushed: 2026-05-01 -> 2026-09-01 2026-04-30
minor Completion pushed: 2026-06-30 -> 2026-10-31 2026-04-30
Trial Details
NCT Number NCT04255160
Lead Sponsor University of Delaware
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
Conditions Perimenopause, Vasodilation, Estrogen
Enrollment 80 participants
Start Date 2020-10-01
Primary Completion 2026-09-01 (estimated)
Study Completion 2026-10-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-29