Application of Functional Renal MRI to Improve Assessment of Chronic Kidney Disease

Research question: Can multiparametric renal Magnetic Resonance Imaging (MRI) provide structural and functional assessment of the kidneys to deliver prognostic information and guide treatment options in chronic kidney disease (CKD)? Aims and objectives: 1. To establish a multiparametric renal MRI protocol in CKD cohorts. 2. To use multiparametric MRI to characterise people with and without CKD progression. 3. To compare multiparametric renal MRI with 'gold-standard' renal biopsy to determine pathological processes of CKD progression that are detectable by MRI.

NCT Number	NCT04238299
Lead Sponsor	University Hospitals of Derby and Burton NHS Foundation Trust Collaborators: University of Nottingham, Queen Elizabeth University Hospital Glasgow, Royal Infirmary of Edinburgh, University of Edinburgh, Newcastle University, Newcastle-upon-Tyne Hospitals NHS Trust, University of Leeds, The Leeds Teaching Hospitals NHS Trust, Sheffield Teaching Hospitals NHS Foundation Trust, University of Sheffield, Northern Care Alliance NHS Foundation Trust, University College, London, University of Cambridge, Cambridge University Hospitals NHS Foundation Trust
Conditions	Chronic Kidney Diseases
Enrollment	486 participants
Start Date	2021-06-01
Primary Completion	2027-02-28 (estimated)
Study Completion	2033-02-28 (estimated)
Updated on ClinicalTrials.gov	2026-05-12