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Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder

StatusNot Yet Recruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗

Record History

  1. Primary completion date: Oct 2027 to Dec 2028
    • Start date: Jun 2025 to Oct 2026
    • Study completion date: Dec 2027 to Dec 2028
    v13
  2. Primary completion date: Oct 2026 to Oct 2027
    • Start date: Oct 2024 to Jun 2025
    • Study completion date: Dec 2026 to Dec 2027
    v12
  3. Study Identification, Study Statusv11
  4. Primary completion date: Oct 2025 to Oct 2026
    • Start date: Oct 2023 to Oct 2024
    • Study completion date: Dec 2025 to Dec 2026
    v10
  5. Primary completion date: Oct 2023 to Oct 2025
    • Start date: Jan 2023 to Oct 2023
    • Study completion date: Dec 2023 to Dec 2025
    v9
Show 7 earlier versionsHide 7 earlier versions
  1. Start date: Mar 2022 to Jan 2023
    • Primary completion date: Jun 2023 to Oct 2023
    v8
  2. Start date: Sep 2021 to Mar 2022v7
  3. Start date: Jul 2021 to Sep 2021v6
  4. Primary completion date: Feb 28, 2022 to Jun 2023
    • Start date: Jan 2021 to Jul 2021
    • Study completion date: Dec 31, 2022 to Dec 2023
    v5
  5. Start date: Sep 2020 to Jan 2021v4
  6. Start date: Jul 1, 2020 to Sep 2020v3
  7. Start date: Mar 1, 2020 to Jul 1, 2020v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This preliminary study is designed to evaluate mechanisms by which excitatory dorsolateral prefrontal cortex (dlPFC) repetitive transcranial magnetic stimulation (rTMS) (vs. sham) and pharmacological stress (vs. placebo) alter behavior in non-treatment seeking individuals with opioid use disorder (OUD). Specific Aims are to (1) Evaluate how stress impacts domains of behavior including (1a) executive function and (1b) opioid-seeking behavior; and (2) Determine whether rTMS stimulation attenuates (2a) executive dysfunction, (2b) stress-reactivity, and (2c) opioid-seeking in individuals with OUD not receiving treatment.
Trial Details
NCT Number NCT04231708
Lead Sponsor Wayne State University
Conditions
(from sponsor)		 Opioid Use Disorder
Related terms Opioid-Related Disorders
Enrollment 20 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov