Clinical Trial

Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder

Not Yet Recruiting Phase 2
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Summary
This preliminary study is designed to evaluate mechanisms by which excitatory dorsolateral prefrontal cortex (dlPFC) repetitive transcranial magnetic stimulation (rTMS) (vs. sham) and pharmacological stress (vs. placebo) alter behavior in non-treatment seeking individuals with opioid use disorder (OUD). Specific Aims are to (1) Evaluate how stress impacts domains of behavior including (1a) executive function and (1b) opioid-seeking behavior; and (2) Determine whether rTMS stimulation attenuates (2a) executive dysfunction, (2b) stress-reactivity, and (2c) opioid-seeking in individuals with OUD not receiving treatment.
Protocol Amendment History 12 amendments
This ClinicalTrials.gov record has been amended 12 times since 2020-01-13; most recent amendment 2025-12-26.
Trial Details
NCT Number NCT04231708
Lead Sponsor Wayne State University
Conditions Opioid Use Disorder
Enrollment 20 participants
Start Date 2026-10
Primary Completion 2028-12 (estimated)
Study Completion 2028-12 (estimated)
Updated on ClinicalTrials.gov 2025-12-30