Clinical Trial

Single- vs. Two-Fraction Spine Stereotactic Radiosurgery for the Treatment of Vertebral Metastases

Recruiting Phase 2

Summary

Spine radiosurgery (SRS) utilizes advanced treatment planning with focused x-rays to deliver one to four high dose treatments to the spine to help relieve pain and/or neurologic symptoms. Spine SRS uses special equipment to position the participant and guide the focused beams toward the area to be treated and away from normal tissue. One of the side effects of spine SRS is the development of vertebral compression fractures, many of which are not painful. The goal of this study is to compare the effects, good and/or bad, of spine SRS given in 1 or 2 treatments. Our main goal is to find out which approach will reduce the chances of developing vertebral compression fractures.

Protocol Amendment History 13 amendments

This ClinicalTrials.gov record has been amended 13 times since 2020-01-02; most recent amendment 2026-06-04.

Status change: Not Yet Recruiting → Recruiting 2020-04-06

Trial Details

NCT Number	NCT04218617
Lead Sponsor	Case Comprehensive Cancer Center
Conditions	Spine Metastases, Spine Stereotactic Radiosurgery (sSRS)
Enrollment	130 participants
Start Date	2020-02-07
Primary Completion	2026-10 (estimated)
Study Completion	2026-10 (estimated)
Updated on ClinicalTrials.gov	2026-08-06