Clinical Trial

Semantic Feature Analysis Treatment for Aphasia

Active, Not Recruiting
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Record status
This record was last updated June 26, 2025 (before its estimated August 30, 2025 completion). Its status may not reflect the trial's current state.
Summary
This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of treatment success. Study participants will be randomly assigned to one of two treatment conditions comparing two different versions of Semantic Feature Analysis treatment. Their performance on standardized and study-specific measures will be used to determine which version of the treatment provides superior outcomes, and measures of automatic language processing and functional brain imaging will also be used to identify the underlying neurocognitive mechanisms associated with positive treatment response.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2019-12-31; most recent amendment 2025-06-25.
Status change: Recruiting → Active, Not Recruiting 2025-06-25
Status change: Not Yet Recruiting → Recruiting 2020-01-08
Trial Details
NCT Number NCT04215952
Lead Sponsor VA Pittsburgh Healthcare System
Collaborators: Penn State University
Conditions Aphasia
Enrollment 40 participants
Start Date 2020-02-24
Primary Completion 2025-08-30 (estimated)
Study Completion 2025-08-30 (estimated)
Updated on ClinicalTrials.gov 2025-06-26