Direct Information to At-risk Relatives

This study evaluates if uptake of genetic counselling in high-risk families is increased when patients at cancer genetics clinics are being offered healthcare-assisted disclosure to at-risk relatives compared to current standard care (with family-mediated disclosure). Patients/families who have undergone a cancer genetic investigation will be invited to participate in the study. All participants will receive standard care. Half of them will in addition be offered a healthcare-assisted disclosure with the service of direct letters to identified at-risk relatives distributed by the healthcare provider. After a year we will compare the proportion of at-risk relatives who have contacted a cancer genetic clinics in each study arm.

NCT Number	NCT04197856
Lead Sponsor	Umeå University Collaborators: Göteborg University, Lund University, Karolinska Institutet
Conditions	Familial Breast Cancer, Familial Colorectal Cancer, Hereditary Breast and Ovarian Cancer Syndrome, Hereditary Breast Cancer, Lynch Syndrome
Enrollment	490 participants
Start Date	2020-02-06
Primary Completion	2023-12-31 (estimated)
Study Completion	2025-07-01 (estimated)
Updated on ClinicalTrials.gov	2024-07-09