Clinical Trial

Treatment of Locally Advanced VULvar CArcinoma in a Neoadjuvant Setting With Carboplatin and Paclitaxel Chemotherapy (VULCANize)

Study acronym: VULCANize
Recruiting Phase 2
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Record status
This record was last updated October 19, 2022 (before its estimated January 1, 2024 completion). Its status may not reflect the trial's current state.
Summary
Vulvar cancer is a rare malignancy. Surgery is the treatment of choice, but frequently causes invalidating and chronic postoperative morbidity, especially in patients with high stage disease. Theoretically, downstaging with neoadjuvant chemotherapy could shrink the tumour, making surgical treatment less extensive thereby diminishing the chance for morbidity.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2019-12-09; most recent amendment 2022-10-18.
Status change: Not Yet Recruiting → Recruiting 2020-06-25
Trial Details
NCT Number NCT04192253
Lead Sponsor The Netherlands Cancer Institute
Conditions Locally Advanced, Squamous Cell Carcinoma of the Vulva
Enrollment 51 participants
Start Date 2020-01-14
Primary Completion 2024-01-01 (estimated)
Study Completion 2029-01-01 (estimated)
Updated on ClinicalTrials.gov 2022-10-19