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S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer

StatusActive, Not Recruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

  1. Trial status: Recruiting to Active, Not Recruiting Primary completion date changed from estimate of Nov 15, 2026 to Mar 17, 2026 · Site details revised at 446 of 446 sitesv18 Show 2 more changesShow less
    • Primary completion date changed from estimate of Nov 15, 2026 to Mar 17, 2026
    • Site details revised at 446 of 446 sites
  2. Primary completion date: Nov 15, 2025 to Nov 15, 2026 Study sites: 341 to 446 · Completion date: Nov 15, 2027 to Nov 15, 2029v17 Show 2 more changesShow less
    • Study sites: 341 to 446
    • Completion date: Nov 15, 2027 to Nov 15, 2029
  3. Study title shortened, about 1 wordv16 See this version in full on ClinicalTrials.gov ↗
  4. Start date: Jan 10, 2020 to May 4, 2020v15
  5. Study sites: 277 to 341v14
Show 12 earlier versionsHide 12 earlier versions
  1. Re-verified, no change to tracked fieldsv13
  2. Study sites: 214 to 277v12
  3. Re-verified, no change to tracked fieldsv11
  4. Study sites: 142 to 214v10
  5. Study sites: 107 to 142v9
  6. Study sites: 93 to 107v8
  7. Study title expanded, about 3 wordsv7 See this version in full on ClinicalTrials.gov ↗
  8. Study sites: 24 to 93v6
  9. Study sites: 15 to 24v5
  10. Re-verified, no change to tracked fieldsv4
  11. Study sites: 1 to 15v3
  12. Trial status: Not Yet Recruiting to Recruiting Study sites: 0 to 1v2 Show 1 more changeShow less
    • Study sites: 0 to 1
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI and prolong patients' lifespan. Monitoring with MRI scans alone (delaying radiation until the actual spread of the cancer) may be at least as good as the combination of PCI with MRI scans.
Trial Details
NCT Number NCT04155034
Lead Sponsor SWOG Cancer Research Network
Collaborators: National Cancer Institute (NCI)
Conditions Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma, Lung Small Cell Carcinoma
Enrollment 668 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov