Clinical Trial

Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal Fissure

Study acronym: MEBO
Unknown Phase 2
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Record status
This record was last updated January 29, 2025 (before its estimated January 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
No study to date has compared topical DTZ to MEBO ointment in the treatment of anal fissure. Therefore, the present study aims to compare the efficacy and safety of DTZ to MEBO in the treatment of acute anal fissure. The investigators propose to conduct a comparative randomized clinical study. In this study, the investigators will compare patients with acute anal fissure receiving MEBO ointment vs Topical DTZ ointment vs a combination of MEBO and DTZ ointment. Hypothesis: MEBO in combination with DTZ is more effective than DTZ or MEBO alone in the treatment of acute anal fissure.
Protocol Amendment History 1 change
critical Trial status changed: Recruiting → Unknown 2026-08-02
Trial Details
NCT Number NCT04153032
Lead Sponsor American University of Beirut Medical Center
Conditions Anal Fissure
Enrollment 183 participants
Start Date 2019-12-01
Primary Completion 2026-01-01 (estimated)
Study Completion 2026-01-30 (estimated)
Updated on ClinicalTrials.gov 2025-01-29