Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT04137757 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.
NotablePrimary and study completion pushed from Dec 1, 2026 to Dec 1, 2027
Eligibility criteria expanded, about 13 words
Secondary endpoints: details revised at 1 of 4 entries
NotablePrimary and study completion dates: Dec 1, 2025 to Dec 1, 2026v22
MinorTrial status: Recruiting to Active, Not Recruiting
Enrollment target: estimated 55 to confirmed 21
Site details revised
v21
MinorRe-verified, no change to tracked fieldsv20
NotablePrimary and study completion dates: Dec 1, 2024 to Dec 1, 2025
Eligibility criteria expanded, about 65 words
Site contact updated
v19
Show 17 earlier versionsHide 17 earlier versions
MinorRe-verified, no change to tracked fieldsv18
NotablePrimary and study completion dates: Feb 1, 2024 to Dec 1, 2024v17
Minor3 versionsRe-verified since Jun 2, 2022, no change to tracked fieldsv14-v16
NotableTrial status: Not Yet Recruiting to Recruiting
Study sites: 0 to 1
Start date changed from estimate of Feb 1, 2022 to Feb 18, 2022
v13
MinorEligibility criteria expanded, about 11 words
Secondary endpoints: 5 to 4
Study description expanded, about 1 word
v12
NotableStart date: Aug 1, 2021 to Feb 1, 2022v11
MinorRe-verified, no change to tracked fieldsv10
NotableStart date: Feb 1, 2021 to Aug 1, 2021v9
NotableStart date: Dec 1, 2020 to Feb 1, 2021
Primary and study completion dates: Dec 1, 2023 to Feb 1, 2024
v8
NotablePrimary and study completion dates: Dec 1, 2022 to Dec 1, 2023
Start date: Jul 1, 2020 to Dec 1, 2020
v7
MinorRe-verified, no change to tracked fieldsv6
NotableStart date: Apr 1, 2020 to Jul 1, 2020v5
NotableStart date: Mar 1, 2020 to Apr 1, 2020
Interventions: Lower Body Negative Pressure (Device), Sham Pressure (Device) to Lower Body Negative Pressure (Other), Sham Pressure (Other)
Eligibility criteria expanded, about 24 words
Study description expanded, about 185 words
v4
NotableStart date: Dec 1, 2019 to Mar 1, 2020v3
MinorSecondary endpoints: details revised at 2 of 5 entriesv2
MinorStudy First Submitted
Stopped: an ongoing trial was terminated, suspended or withdrawn.
Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Postural tachycardia syndrome (POTS) is one of the most common forms of chronic orthostatic intolerance in the United States. This is a disabling disorder characterized by an excessive increase in heart rate upon standing that is accompanied by symptoms such as dizziness and fatigue. One of the most under appreciated and bothersome symptoms of POTS is impaired cognition or "brain fog," which occurs to a level that interferes with daily activities such as work and education. Despite this high impact, the reasons why POTS patients have problems with cognition are not well understood. This project will test the overall hypothesis that "brain fog" in POTS is related to increased activation of cognitive brain regions during mental tasks when compared with healthy subjects, and that this activation is exacerbated by in the presence of orthostatic stress.