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Alpha-1 Blockade for Alcohol Use Disorder (AUD)

Study acronym: DOXY
StatusActive, Not Recruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 4 months later Aug 31, 2026 → Dec 31, 2026
See other at-risk trials from Brown University

Record History

See every version on ClinicalTrials.gov ↗

  1. Eligibility criteria expanded, about 19 words
    • Publications: details revised at 2 of 2 entries
  2. Enrollment closed, study ongoing
    • Primary and study completion pushed from Aug 31, 2026 to Dec 31, 2026
    • Start date: Dec 19, 2019 to Aug 19, 2019
    • Site details revised
    v14
  3. Primary and study completion dates: Dec 20, 2025 to Aug 31, 2026
    • Publications: details revised at 2 of 2 entries
    v13
  4. Re-verified, no change to tracked fieldsv12
  5. Publications: details revised at 2 of 2 entriesv11
Show 9 earlier versionsHide 9 earlier versions
  1. Primary and study completion dates: Dec 20, 2024 to Dec 20, 2025v10
  2. Eligibility criteria shortened, about 3 wordsv9
  3. 2 versions Re-verified since Jul 26, 2021, no change to tracked fieldsv7-v8
  4. Primary and study completion dates: Dec 1, 2024 to Dec 20, 2024v6
  5. Primary completion date: Dec 1, 2023 to Dec 1, 2024
    • Start date: Jan 6, 2020 to Dec 19, 2019
    v5
  6. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 0 to 1
    v4
  7. Start date: Dec 1, 2019 to Jan 6, 2020v3
  8. Secondary endpoints: details revised at 2 of 2 entriesv2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this research is to replicate findings previously conducted in a pilot trial and to understand, mechanistically, the role of stress in the development of AUD pharmacotherapies that target noradrenergic blockade.
Trial Details
NCT Number NCT04135846
Lead Sponsor Brown University
Conditions
(from sponsor)		 Alcohol Use Disorder (AUD)
Related terms Alcoholism
Enrollment 184 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov