An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects

Long bone defect (LBD) is defined as a focalized loss of bone tissue in any long bone of the upper or lower extremity. Long bone defects are a complex problem, that may arise as a complication of many different pathologies, such as trauma, tumors or infection. Whereas post-traumatic defects are the largest group. Reports estimate that there are almost 4 million bone grafting procedures worldwide per year. However, limb reconstruction in the context of a bony defect is challenging and up to date there is little evidence and treatment recommendations. In a multi-national approach, the aim of this project is to set up an international, multicenter registry to gather information and details on prevalence or incidence, current treatments, complications and outcome.

NCT Number	NCT04112992
Lead Sponsor	AO Innovation Translation Center
Conditions	Limb Fracture, Bone Loss
Enrollment	600 participants
Start Date	2024-07-03
Primary Completion	2028-05-31 (estimated)
Study Completion	2029-03-30 (estimated)
Updated on ClinicalTrials.gov	2025-08-29