Clinical Trial

Acute Exposure to Diesel: Prolong Effects on Inflammation and Vasculature

Study acronym: DEVA
Recruiting
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Record status
This record was last updated September 24, 2019 (before its estimated December 31, 2024 completion). Its status may not reflect the trial's current state.
Summary
Cross-over double-blind study. Healthy subjects will be exposed to diesel exhaust fumes and/or filtered air during a 2-hour session. Several parameters will be assesed i.e. endothelial function will be assessed with flow mediated dilation (FMD) techniques, arterial stiffness with pulse wave velocity (PWV) and reflected waves with augmentation index (AIx). C reactive protein (CRP), fibrinogen, protein C levels and protein S activity will be also measured. Heart rate variability and standard deviation of normal to normal intervals R-R intervals (SDNN) will be used to assess sympathetic activity. Measurements were assessed before, 2 and 24 hours after diesel exposure.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2019-09-20.
Trial Details
NCT Number NCT04098536
Lead Sponsor University of Athens
Conditions Atherosclerosis
Enrollment 40 participants
Start Date 2015-01-01
Primary Completion 2024-12-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2019-09-24