Clinical Trial

Induction of Gut Permeability by an Oral Vaccine

Active, Not Recruiting Early Phase 1
View on ClinicalTrials.gov →
Summary
This study evaluates the effect of an oral typhoid vaccine on disruption of the intestinal barrier and response of the immune system. Intestinal and whole-body responses will be measured in all participants before and after the vaccine.
Protocol Amendment History 13 amendments
This ClinicalTrials.gov record has been amended 13 times since 2019-09-05; most recent amendment 2025-11-18.
Status change: Recruiting → Active, Not Recruiting 2022-03-02
Status change: Not Yet Recruiting → Recruiting 2019-11-01
Trial Details
NCT Number NCT04083950
Lead Sponsor USDA, Western Human Nutrition Research Center
Conditions Intestinal Permeability, Inflammation, Vaccine, Typhoid Fever
Enrollment 10 participants
Start Date 2019-12-04
Primary Completion 2022-01-31 (estimated)
Study Completion 2026-09-30 (estimated)
Updated on ClinicalTrials.gov 2025-11-24