Clinical Trial

TNF-α Treatment of Blast-Induced Tinnitus

Recruiting Phase 2
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Summary
The purpose of this multi-site research study is to determine if Etanercept, compared to a placebo, significantly reduces the severity of tinnitus (ringing in the ears) associated with history of blast and/or noise exposure or associated with Traumatic Brain Injury (TBI) and/or concussion. Individuals who qualify will be randomized into one of two groups: The group receiving the medication Etanercept or the group receiving a saline solution placebo.
Protocol Amendment History 12 amendments
This ClinicalTrials.gov record has been amended 12 times since 2019-08-20; most recent amendment 2026-02-19.
Status change: Not Yet Recruiting → Recruiting 2022-07-12
Trial Details
NCT Number NCT04066348
Lead Sponsor Wayne State University
Collaborators: University of Miami, Michigan Ear Institute
Conditions Tinnitus, Noise Induced
Enrollment 88 participants
Start Date 2022-07-01
Primary Completion 2026-09 (estimated)
Study Completion 2026-09 (estimated)
Updated on ClinicalTrials.gov 2026-02-23