Westlake Precision Birth Cohort

The Westlake Precision Birth Cohort (WeBirth) is a prospective cohort study among women with hyperglycemia during pregnancy and their offspring living in Hangzhou, China. The primary aim of this cohort is to characterize the continuous blood glucose response to dietary intake and physical activity among pregnant women with gestational diabetes mellitus (GDM) over 2 weeks, and to facilitate the development of personalized nutritional/lifestyle recommendation among these patients. Another aim of WeBirth is to investigate the association of dietary intake and physical activity together with continuous glucose change during pregnancy on the adverse birth outcomes including preterm birth, macrosomia and large-for-gestational-age birth. The secondary aim is to investigate the prospective associations of diet, physical activity and continuous glucose change over 2 weeks among the participants with long-term metabolic health of these women and their offspring.

NCT Number	NCT04060056
Lead Sponsor	Westlake University Collaborators: Hangzhou Maternal and Child Health Hospital
Conditions	Diabetes, Gestational, Pregnancy in Diabetics, Intrauterine Hyperglycemia
Enrollment	2,001 participants
Start Date	2019-08-30
Primary Completion	2025-11-30 (estimated)
Study Completion	2029-08-31 (estimated)
Updated on ClinicalTrials.gov	2025-04-03