Clinical Trial

Osteopathic Manipulation Makes a Neuropsychological Difference

Study acronym: BOD

Active, Not Recruiting

Summary

Patients with pain commonly experience cognitive impairment. While symptoms of pain are effectively treated with osteopathic manipulative treatment (OMT), the cognitive piece is vastly ignored. Pain-induced cognitive dysfunction can be severe and is particularly apparent in working memory and attention. There is good reason to also expect cognitive responsiveness to OMT. Previous research has already reported related psychiatric outcomes, including relief from stress, self-perception and anxiety, suggesting that OMT may produce more global effects on cortical processing than currently thought.

Protocol Amendment History 4 amendments

This ClinicalTrials.gov record has been amended 4 times since 2019-08-14; most recent amendment 2025-09-24.

Status change: Recruiting → Active, Not Recruiting 2021-03-16

Trial Details

NCT Number	NCT04058431
Lead Sponsor	Midwestern University
Conditions	Cognitive Change, Musculoskeletal Pain
Enrollment	100 participants
Start Date	2017-01
Primary Completion	2026-09 (estimated)
Study Completion	2026-09 (estimated)
Updated on ClinicalTrials.gov	2025-09-30