Clinical Trial

E-CEL UVEC Cells as an Adjunct Cell Therapy for the Arthroscopic Rotator Cuff Repair in Adults

Enrolling by Invitation Phase 1
View on ClinicalTrials.gov →
Summary
This is a phase 1b investigator-initiated clinical trial that will evaluate the safety and feasibility of E-CEL UVEC® cells with the aim of improving outcomes for patients with full-thickness rotator cuff tears who undergo arthroscopic surgical repair. Allogeneic E-CEL UVEC cells will be delivered to the tendon repair site and to the muscle adjacent to the tendon repair site.
Protocol Amendment History 12 amendments
This ClinicalTrials.gov record has been amended 12 times since 2019-08-13; most recent amendment 2025-11-19.
Status change: Active, Not Recruiting → Enrolling by Invitation 2024-11-15
Status change: Recruiting → Active, Not Recruiting 2022-08-05
Status change: Not Yet Recruiting → Recruiting 2019-11-05
Trial Details
NCT Number NCT04057833
Lead Sponsor Hospital for Special Surgery, New York
Collaborators: Angiocrine Bioscience
Conditions Rotator Cuff Tears, Muscle Atrophy or Weakness, Tendon Rupture - Shoulder, Safety Issues
Enrollment 20 participants
Start Date 2019-11-20
Primary Completion 2026-10 (estimated)
Study Completion 2026-10 (estimated)
Updated on ClinicalTrials.gov 2025-11-26