Exercise, Arterial Modulation and Nutrition in Youth South Africa Study

The ExAMIN Youth SA study aims to generate new knowledge on the pathophysiology involved in early vascular aging among South African children and to identify early novel biological markers for predicting the subclinical development of hypertension and target organ damage related to cardiovascular disease. This study further implements state-of-the-art biochemical technology to measure a variety of biological markers including multiplex analyses and metabolomics. With the increasing prevalence of childhood hypertension and obesity, this study will be able to address especially behavioural contributors to hypertension development and to subsequently provide a backdrop for school-based primary prevention interventions.

NCT Number	NCT04056377
Lead Sponsor	North-West University, South Africa Collaborators: National Research Foundation of South Africa, Medical Research Council, South Africa
Conditions	Hypertension, Retinal Artery Stenosis, Childhood Obesity
Enrollment	1,065 participants
Start Date	2017-09-12
Primary Completion	2019-04-30 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-04-13