Clinical Trial

High Frequency Light and Sound Stimulation to Improve Brain Functions in Alzheimer's Disease

Active, Not Recruiting
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Record status
This record was last updated October 1, 2024 (before its estimated April 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
Alzheimer's disease (AD) is characterized by significant memory loss and toxic protein deposits (amyloid and tau) in the brain. The investigators' lab found a non-invasive way to remove these toxic proteins from the brain in AD mouse models. Remarkably, treated mice also have improved memory on behavioral testing. The investigators aim to translate this non-invasive method, which uses light and sound to stimulate the brain, to be used in mild Alzheimer's patients. 40 participants with mild Alzheimer's disease will be recruited, and the investigators will assess their brain waves with electroencephalogram (EEG) before, during, and after light and sound stimulation for safety, feasibility, and to optimize the stimulation device for use in the mild AD population.
Protocol Amendment History 7 amendments
This ClinicalTrials.gov record has been amended 7 times since 2019-08-01; most recent amendment 2024-09-27.
Status change: Recruiting → Active, Not Recruiting 2020-04-21
Trial Details
NCT Number NCT04042922
Lead Sponsor Massachusetts Institute of Technology
Conditions Alzheimer Disease
Enrollment 80 participants
Start Date 2019-04-19
Primary Completion 2026-04-30 (estimated)
Study Completion 2027-04-30 (estimated)
Updated on ClinicalTrials.gov 2024-10-01