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High Frequency Light and Sound Stimulation to Improve Brain Functions in Alzheimer's Disease

StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated October 1, 2024 (before its estimated April 30, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Re-verified, no change to tracked fieldsv8
  2. Primary completion date: Apr 30, 2024 to Apr 30, 2026 Completion date: Apr 30, 2025 to Apr 30, 2027v7 Show 1 more changeShow less
    • Completion date: Apr 30, 2025 to Apr 30, 2027
  3. Primary completion date: Apr 30, 2023 to Apr 30, 2024 Completion date: Apr 30, 2023 to Apr 30, 2025v6 Show 1 more changeShow less
    • Completion date: Apr 30, 2023 to Apr 30, 2025
  4. Primary and study completion dates: Apr 30, 2021 to Apr 30, 2023v5
  5. Re-verified, no change to tracked fieldsv4
Show 2 earlier versionsHide 2 earlier versions
  1. Enrollment target: 40 to 80v3
  2. Trial status: Recruiting to Active, Not Recruiting Site details revisedv2 Show 1 more changeShow less
    • Site details revised
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Alzheimer's disease (AD) is characterized by significant memory loss and toxic protein deposits (amyloid and tau) in the brain. The investigators' lab found a non-invasive way to remove these toxic proteins from the brain in AD mouse models. Remarkably, treated mice also have improved memory on behavioral testing. The investigators aim to translate this non-invasive method, which uses light and sound to stimulate the brain, to be used in mild Alzheimer's patients. 40 participants with mild Alzheimer's disease will be recruited, and the investigators will assess their brain waves with electroencephalogram (EEG) before, during, and after light and sound stimulation for safety, feasibility, and to optimize the stimulation device for use in the mild AD population.
Trial Details
NCT Number NCT04042922
Lead Sponsor Massachusetts Institute of Technology
Conditions Alzheimer Disease
Enrollment 80 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov