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A Pilot Study of an Antioxidant Cocktail vs. Placebo in the Treatment of Children and Adolescents With Rett Syndrome

StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 1 year 1 month later Nov 30, 2026 → Dec 30, 2027
See other at-risk trials from Holland Bloorview Kids Rehabilitation Hospital

Record History

  1. Notable Recruitment opened Start date: Aug 17, 2026 to Aug 24, 2026 · Site details revisedv7 Show 2 more changesShow less
    • Start date: Aug 17, 2026 to Aug 24, 2026
    • Site details revised
  2. Notable Primary and study completion pushed from Nov 30, 2026 to Dec 30, 2027 Start date: Oct 1, 2025 to Aug 17, 2026 · Site contact updatedv6 Show 2 more changesShow less
    • Start date: Oct 1, 2025 to Aug 17, 2026
    • Site contact updated
  3. Notable Lead sponsor: Anagnostou, Evdokia, M.D. to Holland Bloorview Kids Rehabilitation Hospital Start date: May 1, 2025 to Oct 1, 2025 · Site contact updated · Collaborators: 3 to 2v5 Show 3 more changesShow less
    • Start date: May 1, 2025 to Oct 1, 2025
    • Site contact updated
    • Collaborators: 3 to 2

    See this version in full on ClinicalTrials.gov ↗

  4. Minor Re-verified, no change to tracked fieldsv4
  5. Notable Primary and study completion dates: Jan 31, 2021 to Nov 30, 2026 Start date: Sep 1, 2019 to May 1, 2025 · Site contact updatedv3 Show 2 more changesShow less
    • Start date: Sep 1, 2019 to May 1, 2025
    • Site contact updated
  6. Notable Start date: Aug 1, 2019 to Sep 1, 2019v2
  7. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study will examine the potential efficacy and safety of Rett-T for core motor deficits of Rett syndrome, and will explore biological markers of safety and treatment response.
Trial Details
NCT Number NCT04041713
Lead Sponsor Holland Bloorview Kids Rehabilitation Hospital
Collaborators: Ontario Brain Institute, Unity Health Toronto
Conditions Rett Syndrome
Enrollment 35 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov