Clinical Trial

Biomarker-guided rTMS for Treatment Resistant Depression

Study acronym: BioTMS
Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
Repetitive transcranial magnetic stimulation (rTMS) is a treatment for depression. The investigators are continuing to learn how to optimize outcomes from rTMS treatment. The purpose of this research project is to use brain network connectivity patterns as measured by resting state functional magnetic resonance imaging (fMRI) to confirm a way to optimize the use of rTMS to treat depression. In addition, the study aims to gain a better understanding of how rTMS influences brain networks.
Protocol Amendment History 12 amendments
This ClinicalTrials.gov record has been amended 12 times since 2019-07-31; most recent amendment 2026-02-24.
Status change: Not Yet Recruiting → Recruiting 2021-09-20
Trial Details
NCT Number NCT04041479
Lead Sponsor Weill Medical College of Cornell University
Collaborators: National Institute of Mental Health (NIMH), Stanford University
Conditions Treatment Resistant Depression, Major Depressive Disorder
Enrollment 348 participants
Start Date 2021-09-17
Primary Completion 2027-04 (estimated)
Study Completion 2027-08 (estimated)
Updated on ClinicalTrials.gov 2026-02-25