Clinical Trial

Ozone Application Before Fissure Sealants

Recruiting
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Summary
Decay is a multifactorial infective degenerative disease of hard dental tissues, caused by Streptococcus mutans and Lactobacillus forming the bacterial biofilm of teeth surfaces. Decays generally evolve in fissures and pits of secondary molars. Pits and fissure sealants prevent decays if performed in two years from eruption. Ozone has bactericidal effect and remineralizing capacity on enamel. The aim of this study is to assess the effectiveness of ozone application before sealants in increasing their duration in time.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2019-07-30; most recent amendment 2025-05-13.
Status change: Not Yet Recruiting → Recruiting 2019-10-01
Trial Details
NCT Number NCT04040920
Lead Sponsor IRCCS Burlo Garofolo
Conditions Caries,Dental
Enrollment 67 participants
Start Date 2019-06-17
Primary Completion 2026-12-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-05-16