Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Stroke Patients

Elevated blood pressure (BP) consists of a major public health concern especially in low and middle income countries. Besides being a highly prevalent condition, it is also a risk factor for several major cardiovascular events including stroke (which consists of the second leading cause of death in developing countries) and coronary artery disease, and is also related to cognitive decline. The OPTIMAL Stroke trial consists of a two-arm, multicenter, randomized clinical trial designed to test whether a lower target systolic blood pressure (SBP) as compared to the currently recommended target for stroke patients will reduce the occurrence of major cardiovascular events.

NCT Number	NCT04036409
Lead Sponsor	Hospital Israelita Albert Einstein Collaborators: Ministry of Health, Brazil
Conditions	Ischemic Stroke, Blood Pressure, Cognitive Impairment, Vascular Diseases
Enrollment	4,368 participants
Start Date	2019-08-05
Primary Completion	2026-07-08 (estimated)
Study Completion	2026-07-08 (estimated)
Updated on ClinicalTrials.gov	2026-08-13