Impact of Insomnia Treatment on Brain Responses During Resting-state and Cognitive Tasks

Individuals with chronic insomnia have persistent difficulty falling and staying asleep, as well as complaints of altered daytime functioning that may be associated with cognitive impairments. The neural processes underlying these daytime complaints may involve abnormal activation of brain regions and neural networks involved in working memory, memory encoding and emotions. The goal of this study is to assess whether a psychological treatment for insomnia will reverse these abnormalities in brain responses to cognitive tasks and at rest. A secondary objective of the study is to characterize impairments in attentional processing and assess if the impairments can be reversed by the psychological treatment. We hypothesized that the psychological treatment for insomnia will lead to a normalization of the brain responses to working memory, declarative memory encoding, insomnia-related stimuli, and the functional connectivity within the default-mode and limbic networks.

NCT Number	NCT04024787
Lead Sponsor	Concordia University, Montreal Collaborators: Canadian Institutes of Health Research (CIHR)
Conditions	Chronic Insomnia
Enrollment	120 participants
Start Date	2019-07-30
Primary Completion	2026-05-30 (estimated)
Study Completion	2026-12-30 (estimated)
Updated on ClinicalTrials.gov	2026-03-18