Clinical Trial

Development of Variable Volume Automated Mandatory Boluses for Patient-controlled Epidural Analgesia During Labour

Study acronym: VVAMB
Active, Not Recruiting Phase 3
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Summary
A novel epidural delivery regimen was developed: Variable volume automated mandatory bolus (AMB) (VVAMB) will advance individualisation of labour epidural analgesia, by which a larger volume of bolus may contribute to better spread of the local anaesthetics within brief period and thereby reduces the chances of motor blockade that could reduce instrumental deliveries.
Protocol Amendment History 3 changes
critical Enrollment closed, study ongoing 2026-08-15
notable Primary completion moved earlier: 2025-12-31 -> 2022-07-28 2026-08-15
minor Completion pushed: 2026-08-31 -> 2027-08-31 2026-08-15
Trial Details
NCT Number NCT04011150
Lead Sponsor KK Women's and Children's Hospital
Conditions Labor Pain, Breakthrough Pain
Enrollment 197 participants
Start Date 2020-08-11
Primary Completion 2022-07-28 (estimated)
Study Completion 2027-08-31 (estimated)
Updated on ClinicalTrials.gov 2026-08-14