Clinical Trial

The Cryopreserved vs. Liquid Platelets Trial

Study acronym: CLIP II
Active, Not Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
This trial is a phase III multicentre blinded randomised controlled clinical non-inferiority trial of cryopreserved platelets vs. conventional liquid-stored platelets for the management of surgical bleeding. The aim of the study is to assess the efficacy, safety and cost effectiveness of cryopreserved platelets, compared to conventional liquid-stored platelets, for the management of surgical bleeding. This trial will recruit cardiac surgical patients deemed to be at high risk of surgical bleeding and who may potentially require transfusion of platelets. It is estimated to require 808 high-risk cardiac surgical patients to be recruited, to obtain 202 patients who receive transfused study platelets for surgical bleeding.
Protocol Amendment History 14 amendments
This ClinicalTrials.gov record has been amended 14 times since 2019-06-17; most recent amendment 2025-01-01.
Status change: Recruiting → Active, Not Recruiting 2024-04-15
Status change: Not Yet Recruiting → Recruiting 2021-08-26
Trial Details
NCT Number NCT03991481
Lead Sponsor Australian and New Zealand Intensive Care Research Centre
Collaborators: Australian Red Cross
Conditions Surgical Blood Loss, Hemorrhage
Enrollment 388 participants
Start Date 2021-08-17
Primary Completion 2024-07-17 (estimated)
Study Completion 2025-11 (estimated)
Updated on ClinicalTrials.gov 2025-01-03