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Gene Expression Changes In Young and Geriatric Skin

StatusRecruiting
PhaseEarly Phase 1
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated February 6, 2025 (before its estimated December 2025 completion). Its status may not reflect the trial's current state.

Record History

  1. Re-verified, no change to tracked fieldsv12
  2. Primary and study completion dates: Dec 2023 to Dec 2025v11
  3. Re-verified, no change to tracked fieldsv10
  4. Primary completion date: Dec 2022 to Dec 2023
    • Study completion date: Jul 2023 to Dec 2023
    v9
  5. Lead sponsor: Jeffrey B. Travers, MD, PhD to Wright State Universityv8
Show 6 earlier versionsHide 6 earlier versions
  1. Primary completion date: Dec 2021 to Dec 2022
    • Study completion date: Jul 2022 to Jul 2023
    v7
  2. Primary completion date: Dec 2020 to Dec 2021
    • Study completion date: Jul 2021 to Jul 2022
    v6
  3. Primary completion date: Jun 2020 to Dec 2020
    • Study completion date: Jun 2020 to Jul 2021
    v5
  4. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Aug 2019 to Sep 6, 2019
    • Site details revised
    v4
  5. Start date: Jun 2019 to Aug 2019v3
  6. Re-verified, no change to tracked fieldsv2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.
Trial Details
NCT Number NCT03932162
Lead Sponsor Wright State University
Conditions
(from sponsor)		 UVB Phototherapy Burn, Insulin-like Growth Factor 1, Aging
Enrollment 24 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov