Cold Snare Endoscopic Mucosal Resection Trial

This study compares different approaches to endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps (≥20mm) in a 2 x 2 randomized design. The first randomization will assign half of patients to polyp resection with electrocautery ("hot" snare EMR) and half of patient to polyp resection without electrocautery ("cold" snare EMR). The second randomization will assign half of patients to polyp removal using Eleview as the submucosal injection agent, and the other half using placebo (normal saline with methylene blue) as the submucosal injection agent.

NCT Number	NCT03865537
Lead Sponsor	White River Junction Veterans Affairs Medical Center Collaborators: Dartmouth College, Steris, Cosmo Pharmaceuticals
Conditions	Colonic Polyp, Colonoscopy, Complication, Recurrence
Enrollment	990 participants
Start Date	2019-10-01
Primary Completion	2024-05-31 (estimated)
Study Completion	2027-01 (estimated)
Updated on ClinicalTrials.gov	2024-06-21