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Tumor Associated Antigen Specific T Cells (TAA-T) With PD1 Inhibitor for Lymphoma

StatusActive, Not Recruiting
PhasePhase 1
Started2019-06-24
View on ClinicalTrials.gov ↗
This is a Phase I, open-label multi-site trial designed to evaluate the safety of administering rapidly-generated Tumor associated antigen specific T cells (TAA-T) with the Programmed Death1 (PD-1) inhibitor Nivolumab, in relapsed/refractory lymphoma (rel/ref) patients with measurable disease (group A) or as adjunctive therapy following autologous hematopoeitic stem cell transplant(HSCT) for patients at high risk of relapse (group B). The purpose of this study is to find out if the tumor specific T cells given with Nivolumab are safe and to learn what the side effects are and if the combination can help patients with relapsed lymphomas.

Amendment history 1 change detected by DataLookout

2026-08-15
minor
Completion pushed: 2026-08 → 2026-12
Trial Details
NCT Number NCT03843294
Lead Sponsor Catherine Bollard
Conditions Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma
Enrollment 18 participants
Start Date 2019-06-24
Primary Completion 2023-05-02 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2026-08-14