Targeted Potassium Levels for Prevention of ICD Therapy

This study evaluates whether a rigorously controlled high-normal level of serum-potassium (4.5-5.0 mEq/L) using dietary recommendations, potassium supplements and mineralocorticoid receptor antagonists will results in a lower incidence of cardiac arrhythmias in patients with an ICD. Patients will be randomized to this treatment or a control arm, where patients will receive usual guideline recommended follow-up.

NCT Number	NCT03833089
Lead Sponsor	Rigshospitalet, Denmark Collaborators: Herlev and Gentofte Hospital
Conditions	Ventricular Arrhythmias and Cardiac Arrest, Implantable Defibrillator User, Hypokalemia, Hyperkalemia, Ventricular Tachycardia, Atrial Fibrillation
Enrollment	1,200 participants
Start Date	2019-03-01
Primary Completion	2025-05-09 (estimated)
Study Completion	2035-04-01 (estimated)
Updated on ClinicalTrials.gov	2025-05-09