Clinical Trial

Nitrite-boosting Therapy for Improving Physiological Function in Patients With Chronic Kidney Disease

Active, Not Recruiting Phase 4
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Record status
This record was last updated March 31, 2026 (before its estimated July 2026 completion). Its status may not reflect the trial's current state.
Summary
Nitric oxide (NO) is an essential molecule in the body that is decreased in patients with chronic kidney disease (CKD), leading to reductions in vascular, movement ("motor") and cognitive functions. This study will determine if daily oral supplementation (3 months) with a supplement that increases NO in the body, i.e., nitrate-rich beetroot juice, improves vascular, motor and cognitive function in patients with CKD; this study will also provide insight into the biological reasons (mechanisms) by which supplementation with nitrate-rich beetroot juice improves vascular function in these patients. Overall, this research will provide scientific evidence supporting the use of nitrate-rich beetroot juice for preserving physiological function and preventing co-morbid clinical conditions and disability in CKD.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2019-01-29; most recent amendment 2026-03-30.
Status change: Recruiting → Active, Not Recruiting 2026-03-30
Status change: Not Yet Recruiting → Recruiting 2019-06-04
Trial Details
NCT Number NCT03826147
Lead Sponsor University of Colorado, Boulder
Conditions Chronic Kidney Disease
Enrollment 92 participants
Start Date 2019-05-01
Primary Completion 2026-07 (estimated)
Study Completion 2026-08 (estimated)
Updated on ClinicalTrials.gov 2026-03-31