Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule

The purpose of present study is to provide clinical evidences for the appropriate management of molar pregnancy with lung nodule. The hydatidiform mole patients with lung nodule ≥1.0cm will be randomized into 2 groups: A. treated with chemotherapy immediately, B. follow up until hCG level met FIGO diagnostic criteria of GTN (B1) or hCG level declined to normal spontaneously (B2). Lung nodule \<1.0cm will directly treated as group C

NCT Number	NCT03785574
Lead Sponsor	Women's Hospital School Of Medicine Zhejiang University Collaborators: Qilu Hospital of Shandong University, Tongji Hospital Affiliated to Tongji Medical College of HUST, The First People's Hospital of Yunnan, Tianjin Central Hospital of Gynecology Obstetrics, Women and Children's Hospital of Ningbo University, First Affiliated Hospital of Wenzhou Medical University, Hangzhou Fuyang Women And Children Hospital, Zhejiang Provincial Tongde Hospital, Shaoxing Shangyu Women And Children Hospital, Huzhou Maternity and Child Health Care Hospital
Conditions	Hydatidiform Mole, Gestational Trophoblastic Neoplasia
Enrollment	30 participants
Start Date	2018-12-24
Primary Completion	2030-09-01 (estimated)
Study Completion	2030-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-16