Clinical Trial

Concordance Between FFR and iFR for the Assessment of Intermediate Lesions in the Left Main Coronary Artery. A Prospective Validation of a Default Value for iFR

Study acronym: iLITRO
Active, Not Recruiting
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Record status
This record was last updated March 5, 2025 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
The assessment of Left Main Coronary Artery (LMCA) lesions by means of coronary angiography renders serious limitations. Studies with a limited number of patients have shown that a value of FFR (Fractional Flow Reserve) above 0.80 identify a low risk of events in case of not performing revascularization in patients with intermediate stenosis in the LMCA. Although iFR (Instant wave Free Ratio) has recently been found equivalent to FFR The demonstration of the prognostic utility of iFR in patients with LMCA intermediate lesions could have an important clinical impact and justify its systematic use for the treatment decision in these high-risk patients.
Protocol Amendment History 23 amendments
This ClinicalTrials.gov record has been amended 23 times since 2018-12-05; most recent amendment 2025-03-03.
Status change: Recruiting → Active, Not Recruiting 2022-07-26
Status change: Not Yet Recruiting → Recruiting 2019-05-06
Trial Details
NCT Number NCT03767621
Lead Sponsor Fundación EPIC
Conditions Coronary Artery Disease, Left Main Coronary Artery Stenosis, Left Main Coronary Artery Disease, Restenosis, Coronary
Enrollment 300 participants
Start Date 2019-02-19
Primary Completion 2026-06-30 (estimated)
Study Completion 2026-11-30 (estimated)
Updated on ClinicalTrials.gov 2025-03-05