TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck

This is a single-arm Phase II study of adjuvant radiation for locally advanced p16+ oropharyngeal squamous cell carcinoma. The main purpose of this research is to determine the likelihood of cancer growing back in the throat or in the neck two years after completion of radiation if lower doses of radiation are used to a smaller area of the head and neck region than is currently used in standard of care.

NCT Number	NCT03729518
Lead Sponsor	Abramson Cancer Center at Penn Medicine
Conditions	Oropharyngeal Cancer, Squamous Cell Carcinoma, Human Papilloma Virus
Enrollment	150 participants
Start Date	2018-10-11
Primary Completion	2026-07-15 (estimated)
Study Completion	2026-07-15 (estimated)
Updated on ClinicalTrials.gov	2026-07-22