Biology of Cerebral Arteriovenous Malformations and Prognosis of Cerebral Arteriovenous Malformations

The cerebral arteriovenous malformations correspond to the formation of an entanglement of morphologically abnormal vessels called nidus, which shunt the blood circulation directly from the arterial circulation to the venous circulation. The cerebral arteriovenous malformations are an important cause of hemorrhagic stroke. The hypothesis is that cerebral haemorrhage associated with a cerebral arteriovenous malformations would come from peri-nidal micro-vessels, in connection with infiltration of leucocytes and / or defective maintenance of microvascular integrity by platelets.

NCT Number	NCT03676868
Lead Sponsor	Fondation Ophtalmologique Adolphe de Rothschild
Conditions	Cerebral Arteriovenous Malformations, Ruptured or Unruptured Cerebral Arteriovenous Malformations
Enrollment	300 participants
Start Date	2018-11-20
Primary Completion	2028-11-19 (estimated)
Study Completion	2028-11-19 (estimated)
Updated on ClinicalTrials.gov	2025-06-25