Sevoflurane Sedation in Patients With Septic Shock

Recent in vivo studies from others as well as the investigators group demonstrated that volatile anesthetics immunomodulate sepsis and improve outcome. Also, several clinical trials have convincingly shown that application of a volatile anesthetic provides protection in patients undergoing major surgery. Patients with sepsis are intubated and ventilated and therefore need sedation. So far, most ICU centers use intravenously applied sedatives in these patients. In the proposed study, we will switch sedation from an intravenous to a volatile anesthetic for a short period of time to explore if sepsis markers improve within the following 120 hours upon sevoflurane conditioning.

NCT Number	NCT03643367
Lead Sponsor	University of Zurich Collaborators: Kantonsspital Münsterlingen, Triemli Hospital, Waid City Hospital, Zurich
Conditions	Shock, Septic
Enrollment	153 participants
Start Date	2026-01
Primary Completion	2027-02 (estimated)
Study Completion	2027-11 (estimated)
Updated on ClinicalTrials.gov	2025-04-01