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Sevoflurane Sedation in Patients With Septic Shock

Study acronym: SSiS
StatusNot Yet Recruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗

Record History

  1. Primary completion date: Feb 2025 to Feb 2027 Start date: Jan 2025 to Jan 2026 · Completion date: Nov 2025 to Nov 2027v6 Show 2 more changesShow less
    • Start date: Jan 2025 to Jan 2026
    • Completion date: Nov 2025 to Nov 2027
  2. Re-verified, no change to tracked fieldsv5
  3. Primary completion date: Feb 2024 to Feb 2025 Start date: Jan 2022 to Jan 2025 · Completion date: Nov 2024 to Nov 2025v4 Show 2 more changesShow less
    • Start date: Jan 2022 to Jan 2025
    • Completion date: Nov 2024 to Nov 2025
  4. Start date: Mar 2020 to Jan 2022v3
  5. Start date: Jan 2019 to Mar 2020 Enrollment target: 116 to 153 · Primary completion date: Dec 2023 to Feb 2024 · Completion date: Jun 2024 to Nov 2024 · 2 morev2 Show 5 more changesShow less
    • Enrollment target: 116 to 153
    • Primary completion date: Dec 2023 to Feb 2024
    • Completion date: Jun 2024 to Nov 2024
    • Interventions: Sevoflurane (Drug) to Control Group (Drug), Sevoflurane (Drug)
    • Study description revised

    See this version in full on ClinicalTrials.gov ↗

  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Recent in vivo studies from others as well as the investigators group demonstrated that volatile anesthetics immunomodulate sepsis and improve outcome. Also, several clinical trials have convincingly shown that application of a volatile anesthetic provides protection in patients undergoing major surgery. Patients with sepsis are intubated and ventilated and therefore need sedation. So far, most ICU centers use intravenously applied sedatives in these patients. In the proposed study, we will switch sedation from an intravenous to a volatile anesthetic for a short period of time to explore if sepsis markers improve within the following 120 hours upon sevoflurane conditioning.
Trial Details
NCT Number NCT03643367
Lead Sponsor University of Zurich
Collaborators: Kantonsspital Münsterlingen, Triemli Hospital, Waid City Hospital, Zurich
Conditions Shock, Septic
Enrollment 153 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov