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Phase II Study of Second- Line Pembrolizumab Plus GVD for Relapsed or Refractory Hodgkin Lymphoma

StatusRecruiting
PhasePhase 2
Started2018-08-01
View on ClinicalTrials.gov ↗
The purpose of this study is to test any good and bad effects of the study drug, pembrolizumab, in combination with GVD in the treatment of Hodgkin lymphoma.

Amendment history 3 changes detected by DataLookout

2026-07-16
critical
Primary endpoint(s) modified
WasComplete response rate (part 1)
NowAssess freedom from disease at 5 years (part 3), Complete response rate (part 1)
2026-07-16
critical
Primary completion pushed: 2026-08 → 2027-08
2026-07-16
minor
Completion pushed: 2026-08 → 2027-08
Trial Details
NCT Number NCT03618550
Lead Sponsor Memorial Sloan Kettering Cancer Center
Collaborators: Merck Sharp & Dohme LLC
Conditions Hodgkin Lymphoma, Relapsed or Refractory Hodgkin Lymphoma
Enrollment 257 participants
Start Date 2018-08-01
Primary Completion 2027-08 (estimated)
Study Completion 2027-08 (estimated)
Updated on ClinicalTrials.gov 2026-08-07