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Liver Transplantation With Tregs at MGH

Study acronym: LITTMUS-MGH
StatusCompleted
PhasePhase 1/2
Started
View on ClinicalTrials.gov ↗

Record History

  1. Primary endpoints: details revised at 2 of 5 entries Trial completed · Study completion date changed from estimate of Apr 6, 2027 to Feb 5, 2026 · Primary completion date: Feb 6, 2026 to Feb 5, 2026 · 3 more Show 6 more changesShow less
    • Trial completed
    • Study completion date changed from estimate of Apr 6, 2027 to Feb 5, 2026
    • Primary completion date: Feb 6, 2026 to Feb 5, 2026
    • Eligibility criteria expanded, about 28 words
    • Secondary endpoints: details revised at 12 of 18 entries
    • Study description revised
  2. Primary completion date changed from estimate of Mar 31, 2026 to Feb 6, 2026v20
  3. Re-verified, no change to tracked fieldsv19
  4. Eligibility criteria shortened, about 33 wordsv18 See this version in full on ClinicalTrials.gov ↗
  5. Trial status: Recruiting to Active, Not Recruiting Site details revisedv17 Show 1 more changeShow less
    • Site details revised
Show 15 earlier versionsHide 15 earlier versions
  1. Completion date: Mar 31, 2027 to Apr 6, 2027v16
  2. Primary completion date: Mar 31, 2025 to Mar 31, 2026 Completion date: Mar 31, 2026 to Mar 31, 2027v15 Show 1 more changeShow less
    • Completion date: Mar 31, 2026 to Mar 31, 2027
  3. Completion date: Apr 6, 2026 to Mar 31, 2026v14
  4. Primary completion date: Mar 31, 2026 to Mar 31, 2025 Completion date: Apr 6, 2027 to Apr 6, 2026v13 Show 1 more changeShow less
    • Completion date: Apr 6, 2027 to Apr 6, 2026
  5. Primary completion date: Mar 2025 to Mar 31, 2026 Completion date: Mar 2026 to Apr 6, 2027v12 Show 1 more changeShow less
    • Completion date: Mar 2026 to Apr 6, 2027
  6. Eligibility criteria shortened, about 16 words Secondary endpoints: details revised at 2 of 18 entriesv11 Show 1 more changeShow less
    • Secondary endpoints: details revised at 2 of 18 entries

    See this version in full on ClinicalTrials.gov ↗

  7. Eligibility criteria shortened, about 28 wordsv10 See this version in full on ClinicalTrials.gov ↗
  8. Primary completion date: Mar 2023 to Mar 2025 Completion date: Mar 2023 to Mar 2026v9 Show 1 more changeShow less
    • Completion date: Mar 2023 to Mar 2026
  9. Primary and study completion dates: Feb 2025 to Mar 2023 Start date: Jan 11, 2019 to Mar 29, 2019v8 Show 1 more changeShow less
    • Start date: Jan 11, 2019 to Mar 29, 2019
  10. Trial status: Not Yet Recruiting to Recruiting Start date changed from estimate of Feb 2019 to Jan 11, 2019 · Site details revisedv7 Show 2 more changesShow less
    • Start date changed from estimate of Feb 2019 to Jan 11, 2019
    • Site details revised
  11. Start date: Dec 2018 to Feb 2019 Primary and study completion dates: Dec 2025 to Feb 2025v6 Show 1 more changeShow less
    • Primary and study completion dates: Dec 2025 to Feb 2025
  12. Start date: Oct 2018 to Dec 2018v5
  13. Start date: Oct 1, 2018 to Oct 2018v4
  14. Re-verified, no change to tracked fieldsv3
  15. Start date: Aug 1, 2018 to Oct 1, 2018v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This is a single-center, prospective, open-label, non-randomized clinical trial exploring cellular therapy to facilitate immunosuppression withdrawal in liver transplant recipients.
Trial Details
NCT Number NCT03577431
Lead Sponsor National Institute of Allergy and Infectious Diseases (NIAID)
Collaborators: Immune Tolerance Network (ITN)
Conditions Liver Transplant
Enrollment 9 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov