Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas

This study evaluates the use of specialized magnetic resonance imaging (MRI) techniques including magnetic resonance (MR) perfusion and 2-hydroxyglutarate (2HG) spectroscopy in the surgical treatment of gliomas. Cohort 1 participants will undergo an MR perfusion scan or 2-HG spectroscopy prior to surgery and intra-operatively. Cohort 2 participants will only undergo standard of care imaging and tumor acquisition. Participant participation will end at the completion of surgery and will be transitioned to standard of care follow-up.

NCT Number	NCT03542409
Lead Sponsor	University of Utah
Conditions	Brain Tumor Adult
Enrollment	53 participants
Start Date	2017-02-15
Primary Completion	2021-10-28 (estimated)
Study Completion	2025-05-14 (estimated)
Updated on ClinicalTrials.gov	2026-08-10